The Study

The Study

SMILE is an international, open label randomized controlled study designed to assess whether cigarette smokers switching to combustion free-nicotine delivery systems (C-F NDS) will undergo measurable improvements in oral health parameters and teeth appearance as a consequence of avoiding exposure to cigarette smoke.

Clinical studies have shown that smoking is a major and multiple risk factors for periodontal diseases on regular smokers compare to non-smokers. 

A 18-months multi-center clinical trial is planned to investigate how avoiding exposure to cigarette smoke may translate into measurable improvement in oral health and teeth appearance.

The subjects who will participate in the study will be: tobacco smokers, including smokers intentioned to switch to cigarette without combustion (C-F NDS), and never been smokers.

The Mission of the research

Tobacco smoke is one of the most important risk factors for periodontitis as it alters the host’s response to plaque.

The mission of the research is: to compare the short-term and long-term impact on oral health among smokers who switch to non-burning nicotine delivery systems and those that continue with cigarette smoking.

Improving health and dental appearance can be a motivational factor to quit smoking for those smokers who are concerned about their oral health and their dental appearance.

The analysis of the image of the supragingival tartar and the measurement of discoloration and tooth stains on the “social six” represent innovative approaches for the evaluation of periodontal health and teeth appearance.

Research in Safety

the perfect combination of the scientific preparation of doctors, innovation in the techniques and tools used, the use of the most effective protection systems against COVID and the benefit of working to obtain a healthy and natural smile for the patient.